Mission: Impossible could refer to:
- Mission: Impossible, the 1966-2025 franchise.
- Mission: Impossible (1966), the 1966-1973 television series starring Steven Hill and Peter Graves.
- Mission: Impossible (1988), the 1988-1990 television series starring Peter Graves.
- Mission: Impossible (1967 novel), the 1967 novel by John Tiger, based on the television series.
- Mission: Impossible (comic series), the 1967 comic series from Dell Publishing, based on the television series.
- Mission: Impossible (television soundtrack), the 1968 soundtrack by Lalo Schifrin, from the television series.
- Mission: Impossible (boardgame), the 1975 boardgame by Berwick Toys, based on the television series.
- Mission: Impossible (1990 video game), the 1990 video game developed by Konami, based on the television series.
- Mission: Impossible (guide), the 1993 guide by Alain Carrazé and Martin Winckler, based on the television series.
- Mission: Impossible (film), the 1996 film starring Tom Cruise.
- Mission: Impossible (comic), the 1996 prequel comic from Marvel Comics, based on the film.
- Mission: Impossible (movie soundtrack), the 1996 soundtrack, from the film.
- Mission: Impossible (score), the 1996 score by Danny Elfman, from the film.
- Mission: Impossible (novelization), the 1996 film novelization by Peter Barsocchini.
- Mission: Impossible (1998 video game), the 1998 video game published by Ocean Software, based on the film.
- Mission: Impossible (2000 video game), the 2000 video game published by Infogrames, also based on the film.