Warren is an American actress and singer. Warren made her Broadway debut in 1963, and in 1965 received wide recognition for playing the title role in the television musical production of Cinderella. In 1985, she starred as one of the prime murder suspects, Miss Scarlet, in the comedy film version of the popular board game Clue. She had recurring roles on the NBC sitcom Will & Grace as Will Truman's father's mistress from 2001 to 2006, and in the ABC comedy-drama Desperate Housewives as Susan Mayer's mother Sophie Bremmer in 2005. From 2008 to 2012, Warren played the role of Jinx Shannon, the lead character's alcoholic mother in the USA Network drama series In Plain Sight.
In 2013, she reunited with Clue castmates Christopher Lloyd and Martin Mull when they guest-starred in an episode of Psych. In 2016, she had a recurring role in the Starz comedy Blunt Talk and in 2018 appeared in the Netflix superhero series Daredevil as Esther Falb.